LABORATORY AND CLINICAL STUDIES ON LIVIDOMYCIN IN SURGICAL FIELD

About 13% of Staphylococcus strains showed a resistance of 100 mcg/ml or more to both lividomycin (LVM) and kanamycin (KM).For LVM, the MIC peak fell on 6.3mcg/ml (47%), and no strain showed a value below 1.6mcg/ml, while for KM 27% of the strains showed a value of 1.6mcg/ml.Thus the results of KM w...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1972/12/25, Vol.25(6), pp.466-471
Main Authors: SHIBATA, KIYOHITO, ITO, TADAO, FUJII, MICHITERU, NISHI, HIDEKI, MURAMATSU, YASUSHI
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - cerebrospinal fluid
Anti-Bacterial Agents - therapeutic use
Anti-Bacterial Agents - urine
Child
Child, Preschool
Drug Resistance, Microbial
Escherichia coli Infections - drug therapy
Female
Humans
Infant
Infant, Newborn
Klebsiella Infections - drug therapy
Male
Middle Aged
Proteus Infections - drug therapy
Pseudomonas Infections - drug therapy
Staphylococcal Infections - drug therapy
Surgical Wound Infection - drug therapy
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Summary:About 13% of Staphylococcus strains showed a resistance of 100 mcg/ml or more to both lividomycin (LVM) and kanamycin (KM).For LVM, the MIC peak fell on 6.3mcg/ml (47%), and no strain showed a value below 1.6mcg/ml, while for KM 27% of the strains showed a value of 1.6mcg/ml.Thus the results of KM were somewhat superior to those of LVM. The blood concentration of LVM administered intramuscularly in a single dose of 500 mg to a healthy adult, showed its maximum level after one hour (36.67mcg/ml on average), and was measured even after 8 hours (1.81mcg/ml on average). The urinary excretion in 24 hours was 82.5%. The transfer of the intramuscularly administered LVM into the spinal fluid was comparatively satisfactory: for human subjects, the concentration of LVM in the fluid was 2-3 times that of KM, and for rabbits, 5-10 times that of KM.The change of blood pressure due to administration of LVM into the medullary cavity of rabbits was almost equal to the changes due to gentamicin (GM) and KM.No particular irritation was found. LVM was administered to 18 cases of surgical infections, and effective in 15 cases (83.3%), No side effect was found except for one case of slightly impaired hearing.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.25.466