Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis

Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-02, Vol.179 (4074), p.689-690
Main Authors: Kies, Marian W., Driscoll, Bernard F., Seil, Fredrick J., Alvord, Ellsworth C.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Antigen-Antibody Reactions
Antigens
Central nervous system
Cerebellum - drug effects
Culture Techniques
Demyelinating diseases
Demyelinating Diseases - immunology
Encephalomyelitis, Autoimmune, Experimental - immunology
Globulins
Guinea Pigs
Immune Sera - pharmacology
Iodine Isotopes
Myelin
Myelin Basic Protein
Myelin basic proteins
Myelin Sheath - immunology
Myelination
Nerve Tissue Proteins
Rabbits - immunology
Sensitization
Spinal Cord - immunology
Tissue culture techniques
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Summary:Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum."
ISSN:0036-8075
1095-9203
DOI:10.1126/science.179.4074.689