Nitroglycerin Sublingual Tablets I: Stability of Conventional Tablets

Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migra...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1973-01, Vol.62 (1), p.122-129
Main Author: Fusari, Salvatore A.
Format: Article
Language:English
Subjects:
and intertablet migration
Autoanalysis
Content uniformity
Content uniformity, nitroglycerin tablets—volatilization and intertablet migration
Drug Packaging
Drug Stability
Drug Storage
Mouth Floor
Nitroglycerin - analysis
Nitroglycerin tablets-stability
nitroglycerin tablets-volatilization and intertablet migration
Nitroglycerin tablets—stability, volatilization, and intertablet migration
nitroglycerin-stability
Placebos
Tablets
Tablets - analysis
Tablets, nitroglycerin—stability, volatilization, and intertablet migration
Temperature
Time Factors
volatilization
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Description
Summary:Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migration are discussed.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600620125