Biological and Phytochemical Evaluation of Plants XI: Isolation of Aspidospermine, Quebrachidine, Rhazinilam, (—)-Pyrifolidine, and Akuammidine from Aspidosperma Quebracho-blanco (Apocynaceae)

• Published in: Journal of pharmaceutical sciences 1973-02, Vol.62 (2), p.218-221
• Main Authors: Lyon, R.L., Fong, H.H.S., Farnsworth, N.R., Svoboda, G.H.
• Format: Article
• Language: English
• Subjects: (-)-pyrifolidine; (-)-Pyrifolidine-isolated from leaves of Aspidosperma quebracho-blanco; akuammidine; Akuammidine-isolated from leaves of Aspidosperma quebracho-blanco; Alkaloids - isolation & purification; Aspidosperma quebracho-blanco leaves-isolation; Aspidosperma quebracho-blanco leaves—isolation, identification of aspidospermine, quebrachidine, rhazinilam, (—)-pyrifolidine, akuammidine; Chromatography, Thin Layer; Crystallization; identification of aspidospermine; identification of constituents from Aspidosperma quebracho-blanco; Mass Spectrometry; Medicinal plants-isolation; Medicinal plants—isolation, identification of constituents from Aspidosperma quebracho-blanco; Plant Extracts - analysis; Plants, Medicinal - analysis; quebrachidine; Quebrachidine-major leaf alkaloid in Aspidosperma quebracho-blanco; rhazinilam; Rhazinilam-new nonindole lactam alkaloid isolted from Aspidosperma quebracho-blanco
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600620206

A phytochemical investigation of the leaves of Aspidosperma quebracho-blanco (Apocynaceae) resulted in the isolation of rhazinilam, a new nonindole lactam alkaloid, in addition to the known bases, aspidospermine, quebrachidine, (—)-pyrifolidine, and akuammidine. Aspidospermine and quebrachidine were the major leaf alkaloids. Akuammidine and (—)-pyrifolidine were isolated from the leaves for the first time, and the isolation of the latter compound confirms its natural occurrence in this plant.