Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma

• Published in: European journal of haematology 2011-01, Vol.86 (1), p.32-37
• Main Authors: Papajík, Tomáš, Mysliveček, Miroslav, Šedová, Zuzana, Buriánková, Eva, Procházka, Vít, Koranda, Pavel, Raida, Luděk, Kubová, Zuzana, Palová, Miroslava, Kučerová, Ladislava, Flodr, Patrik, Jarkovský, Jiří, Dušek, Ladislav, Indrák, Karel
• Format: Article
• Language: English
• Subjects: Adult; Aged; computed tomography; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Humans; Ki-67 Antigen - analysis; L-Lactate Dehydrogenase - analysis; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - diagnostic imaging; Male; Middle Aged; Neoplasm Staging - methods; Neoplasm Staging - standards; non-Hodgkin's lymphoma; positron emission tomography; Positron-Emission Tomography - methods; Positron-Emission Tomography - standards; Prognosis; Sensitivity and Specificity; standardised uptake value
• ISSN: 0902-4441; 1600-0609
• DOI: 10.1111/j.1600-0609.2010.01532.x

Objectives:  Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F‐FDG PET/CT in untreated patients with NHL. Methods:  One hundred and forty‐nine initial staging 18F‐FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined. Results:  The highest mean and median values of SUVmax were observed in patients with diffuse large B‐cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax