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Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma
Objectives: Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called stand...
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| Published in: | European journal of haematology 2011-01, Vol.86 (1), p.32-37 |
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| container_title | European journal of haematology |
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| creator | Papajík, Tomáš Mysliveček, Miroslav Šedová, Zuzana Buriánková, Eva Procházka, Vít Koranda, Pavel Raida, Luděk Kubová, Zuzana Palová, Miroslava Kučerová, Ladislava Flodr, Patrik Jarkovský, Jiří Dušek, Ladislav Indrák, Karel |
| description | Objectives: Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F‐FDG PET/CT in untreated patients with NHL.
Methods: One hundred and forty‐nine initial staging 18F‐FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined.
Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B‐cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax |
| doi_str_mv | 10.1111/j.1600-0609.2010.01532.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_818402564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>818402564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2872-a1ca92f5c733c1ef64e32dff632ec1993262aa52616a30fe73d545220d5c059c3</originalsourceid><addsrcrecordid>eNo9kcuO0zAUhi0EYsrAKyDvZpWOL7GTLFigTi-gESBRBDvLEx933CZOJnZos-fBSejQszm3_z-L8yGEKZnTMW73cyoJSYgkxZyRcUqo4Gx-eoFml8VLNCMFYUmapvQKvQlhTwhhBc1eoytG8izNGZuhP9-j9kZ3xgUwuG-jPgD-rasecGMxzVfJ6m6NG49D1Dvnd_jbcnu72GLnsYdjNWDj9M43k7nV0YGPAR9dfBzn1kI39jj0D3FoIUwHfeOTTWN2B-dvAq6Gun1sav0WvbK6CvDuOV-jH6vldrFJ7r-uPy0-3iclyzOWaFrqgllRZpyXFKxMgTNjreQMSloUnEmmtWCSSs2JhYwbkQrGiBElEUXJr9HN-W7bNU89hKhqF0qoKu2h6YPKaZ4SJmQ6Kt8_K_uHGoxqO1frblD_HzcKPpwFR1fBcNlToiZAaq8mDmrioCZA6h8gdVLLz5upGv3J2e9ChNPFr7uDkhnPhPr5Za0Wdyv5i4tcFfwvycaSbg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>818402564</pqid></control><display><type>article</type><title>Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Papajík, Tomáš ; Mysliveček, Miroslav ; Šedová, Zuzana ; Buriánková, Eva ; Procházka, Vít ; Koranda, Pavel ; Raida, Luděk ; Kubová, Zuzana ; Palová, Miroslava ; Kučerová, Ladislava ; Flodr, Patrik ; Jarkovský, Jiří ; Dušek, Ladislav ; Indrák, Karel</creator><creatorcontrib>Papajík, Tomáš ; Mysliveček, Miroslav ; Šedová, Zuzana ; Buriánková, Eva ; Procházka, Vít ; Koranda, Pavel ; Raida, Luděk ; Kubová, Zuzana ; Palová, Miroslava ; Kučerová, Ladislava ; Flodr, Patrik ; Jarkovský, Jiří ; Dušek, Ladislav ; Indrák, Karel</creatorcontrib><description>Objectives: Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F‐FDG PET/CT in untreated patients with NHL.
Methods: One hundred and forty‐nine initial staging 18F‐FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined.
Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B‐cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax < 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki‐67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P < 0.001). The geometric mean of SUVmax in patients with Ki‐67 ≤ 60 and those with Ki‐67 > 60 was 8.8 and 14.3, respectively (P < 0.001).
Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki‐67 values suggests that SUVmax might have a prognostic values in NHL.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/j.1600-0609.2010.01532.x</identifier><identifier>PMID: 20874822</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; computed tomography ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Humans ; Ki-67 Antigen - analysis ; L-Lactate Dehydrogenase - analysis ; Lymphoma, Non-Hodgkin - diagnosis ; Lymphoma, Non-Hodgkin - diagnostic imaging ; Male ; Middle Aged ; Neoplasm Staging - methods ; Neoplasm Staging - standards ; non-Hodgkin's lymphoma ; positron emission tomography ; Positron-Emission Tomography - methods ; Positron-Emission Tomography - standards ; Prognosis ; Sensitivity and Specificity ; standardised uptake value</subject><ispartof>European journal of haematology, 2011-01, Vol.86 (1), p.32-37</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2872-a1ca92f5c733c1ef64e32dff632ec1993262aa52616a30fe73d545220d5c059c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20874822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papajík, Tomáš</creatorcontrib><creatorcontrib>Mysliveček, Miroslav</creatorcontrib><creatorcontrib>Šedová, Zuzana</creatorcontrib><creatorcontrib>Buriánková, Eva</creatorcontrib><creatorcontrib>Procházka, Vít</creatorcontrib><creatorcontrib>Koranda, Pavel</creatorcontrib><creatorcontrib>Raida, Luděk</creatorcontrib><creatorcontrib>Kubová, Zuzana</creatorcontrib><creatorcontrib>Palová, Miroslava</creatorcontrib><creatorcontrib>Kučerová, Ladislava</creatorcontrib><creatorcontrib>Flodr, Patrik</creatorcontrib><creatorcontrib>Jarkovský, Jiří</creatorcontrib><creatorcontrib>Dušek, Ladislav</creatorcontrib><creatorcontrib>Indrák, Karel</creatorcontrib><title>Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Objectives: Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F‐FDG PET/CT in untreated patients with NHL.
Methods: One hundred and forty‐nine initial staging 18F‐FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined.
Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B‐cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax < 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki‐67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P < 0.001). The geometric mean of SUVmax in patients with Ki‐67 ≤ 60 and those with Ki‐67 > 60 was 8.8 and 14.3, respectively (P < 0.001).
Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki‐67 values suggests that SUVmax might have a prognostic values in NHL.</description><subject>Adult</subject><subject>Aged</subject><subject>computed tomography</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>L-Lactate Dehydrogenase - analysis</subject><subject>Lymphoma, Non-Hodgkin - diagnosis</subject><subject>Lymphoma, Non-Hodgkin - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Neoplasm Staging - standards</subject><subject>non-Hodgkin's lymphoma</subject><subject>positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Positron-Emission Tomography - standards</subject><subject>Prognosis</subject><subject>Sensitivity and Specificity</subject><subject>standardised uptake value</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo9kcuO0zAUhi0EYsrAKyDvZpWOL7GTLFigTi-gESBRBDvLEx933CZOJnZos-fBSejQszm3_z-L8yGEKZnTMW73cyoJSYgkxZyRcUqo4Gx-eoFml8VLNCMFYUmapvQKvQlhTwhhBc1eoytG8izNGZuhP9-j9kZ3xgUwuG-jPgD-rasecGMxzVfJ6m6NG49D1Dvnd_jbcnu72GLnsYdjNWDj9M43k7nV0YGPAR9dfBzn1kI39jj0D3FoIUwHfeOTTWN2B-dvAq6Gun1sav0WvbK6CvDuOV-jH6vldrFJ7r-uPy0-3iclyzOWaFrqgllRZpyXFKxMgTNjreQMSloUnEmmtWCSSs2JhYwbkQrGiBElEUXJr9HN-W7bNU89hKhqF0qoKu2h6YPKaZ4SJmQ6Kt8_K_uHGoxqO1frblD_HzcKPpwFR1fBcNlToiZAaq8mDmrioCZA6h8gdVLLz5upGv3J2e9ChNPFr7uDkhnPhPr5Za0Wdyv5i4tcFfwvycaSbg</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Papajík, Tomáš</creator><creator>Mysliveček, Miroslav</creator><creator>Šedová, Zuzana</creator><creator>Buriánková, Eva</creator><creator>Procházka, Vít</creator><creator>Koranda, Pavel</creator><creator>Raida, Luděk</creator><creator>Kubová, Zuzana</creator><creator>Palová, Miroslava</creator><creator>Kučerová, Ladislava</creator><creator>Flodr, Patrik</creator><creator>Jarkovský, Jiří</creator><creator>Dušek, Ladislav</creator><creator>Indrák, Karel</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma</title><author>Papajík, Tomáš ; Mysliveček, Miroslav ; Šedová, Zuzana ; Buriánková, Eva ; Procházka, Vít ; Koranda, Pavel ; Raida, Luděk ; Kubová, Zuzana ; Palová, Miroslava ; Kučerová, Ladislava ; Flodr, Patrik ; Jarkovský, Jiří ; Dušek, Ladislav ; Indrák, Karel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2872-a1ca92f5c733c1ef64e32dff632ec1993262aa52616a30fe73d545220d5c059c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>computed tomography</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>L-Lactate Dehydrogenase - analysis</topic><topic>Lymphoma, Non-Hodgkin - diagnosis</topic><topic>Lymphoma, Non-Hodgkin - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Neoplasm Staging - standards</topic><topic>non-Hodgkin's lymphoma</topic><topic>positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Positron-Emission Tomography - standards</topic><topic>Prognosis</topic><topic>Sensitivity and Specificity</topic><topic>standardised uptake value</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papajík, Tomáš</creatorcontrib><creatorcontrib>Mysliveček, Miroslav</creatorcontrib><creatorcontrib>Šedová, Zuzana</creatorcontrib><creatorcontrib>Buriánková, Eva</creatorcontrib><creatorcontrib>Procházka, Vít</creatorcontrib><creatorcontrib>Koranda, Pavel</creatorcontrib><creatorcontrib>Raida, Luděk</creatorcontrib><creatorcontrib>Kubová, Zuzana</creatorcontrib><creatorcontrib>Palová, Miroslava</creatorcontrib><creatorcontrib>Kučerová, Ladislava</creatorcontrib><creatorcontrib>Flodr, Patrik</creatorcontrib><creatorcontrib>Jarkovský, Jiří</creatorcontrib><creatorcontrib>Dušek, Ladislav</creatorcontrib><creatorcontrib>Indrák, Karel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papajík, Tomáš</au><au>Mysliveček, Miroslav</au><au>Šedová, Zuzana</au><au>Buriánková, Eva</au><au>Procházka, Vít</au><au>Koranda, Pavel</au><au>Raida, Luděk</au><au>Kubová, Zuzana</au><au>Palová, Miroslava</au><au>Kučerová, Ladislava</au><au>Flodr, Patrik</au><au>Jarkovský, Jiří</au><au>Dušek, Ladislav</au><au>Indrák, Karel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2011-01</date><risdate>2011</risdate><volume>86</volume><issue>1</issue><spage>32</spage><epage>37</epage><pages>32-37</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>Objectives: Positron emission tomography using 2‐[fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose (18F‐FDG) is considered to be the most beneficial imaging method for staging patients with non‐Hodgkin’s lymphoma (NHL). The intensity of 18F‐FDG accumulation may be determined by calculating the so‐called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F‐FDG PET/CT in untreated patients with NHL.
Methods: One hundred and forty‐nine initial staging 18F‐FDG PET/CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined.
Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B‐cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax < 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki‐67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P < 0.001). The geometric mean of SUVmax in patients with Ki‐67 ≤ 60 and those with Ki‐67 > 60 was 8.8 and 14.3, respectively (P < 0.001).
Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki‐67 values suggests that SUVmax might have a prognostic values in NHL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20874822</pmid><doi>10.1111/j.1600-0609.2010.01532.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of haematology, 2011-01, Vol.86 (1), p.32-37 |
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| subjects | Adult Aged computed tomography Female Fluorodeoxyglucose F18 - pharmacokinetics Humans Ki-67 Antigen - analysis L-Lactate Dehydrogenase - analysis Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - diagnostic imaging Male Middle Aged Neoplasm Staging - methods Neoplasm Staging - standards non-Hodgkin's lymphoma positron emission tomography Positron-Emission Tomography - methods Positron-Emission Tomography - standards Prognosis Sensitivity and Specificity standardised uptake value |
| title | Standardised uptake value of 18F-FDG on staging PET/CT in newly diagnosed patients with different subtypes of non-Hodgkin's lymphoma |
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