The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients

Introduction The cannabinoid receptor gene 1 (CNR1) encodes the human cannabinoid receptor CB1. This receptor has a widespread distribution in the central nervous system (CNS), the main ligands being anandamide, 2-araquidonoil glycerol and marijuana constituents. There is evidence to suggest an anti...

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Bibliographic Details
Published in:Clinical & translational oncology 2010-12, Vol.12 (12), p.825-828
Main Authors: Núñez, Mercedes, Perdomo, Sandra, Moreta, Juan, Santos-Briz, Ángel, González-Sarmiento, Rogelio
Format: Article
Language:English
Subjects:
Adult
Alleles
Brief Research Articles
Central Nervous System Neoplasms - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Glioma - genetics
Humans
Male
Medicine
Medicine & Public Health
Meningeal Neoplasms - genetics
Meningioma - genetics
Middle Aged
Oncology
Polymorphism, Genetic
Receptor, Cannabinoid, CB1 - genetics
Spain
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Summary:Introduction The cannabinoid receptor gene 1 (CNR1) encodes the human cannabinoid receptor CB1. This receptor has a widespread distribution in the central nervous system (CNS), the main ligands being anandamide, 2-araquidonoil glycerol and marijuana constituents. There is evidence to suggest an anti-neoplastic effect of these ligands in glial tissues mediated through stimulation of the receptor. Material and methods We have studied the G1359A polymorphism of the gene CNR1 with a TaqMan allelic discrimination assay in 200 patients diagnosed with glioma, 109 patients diagnosed with meningioma and 403 healthy subjects. Results Genotypic distribution of the G1359A CNR1 polymorphism in glioma patients showed significant differences when compared to the control group. Discussion Our results suggest that allele G of the CNR1 gene could be associated with a lower susceptibility to glioma.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-010-0604-7