Amino-Acid Sequence in a Hypertensin

THE isolation and purification of a hypertensin peptide, resulting from the action of rabbit renin on ox serum, have been described recently by one of us. Its amino-acid composition was consistent with a decapeptide structure containing the following eight amino-acids: leucine (1), phenylalanine (1)...

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Bibliographic Details
Published in:Nature (London) 1956-03, Vol.177 (4507), p.527-528
Main Authors: ELLIOTT, D. F, PEART, W. S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids
Angiotensin Amide
Angiotensins
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:THE isolation and purification of a hypertensin peptide, resulting from the action of rabbit renin on ox serum, have been described recently by one of us. Its amino-acid composition was consistent with a decapeptide structure containing the following eight amino-acids: leucine (1), phenylalanine (1), tyrosine (1), proline (1), aspartic acid (1), arginine (1), valine (2) and histidine (2). Application of the fluorodinitrobenzene technique of Sanger showed that the N-terminal residue was aspartic acid 1 . The amino-acid sequence in this peptide has been determined by the following methods:
ISSN:0028-0836
1476-4687
DOI:10.1038/177527a0