Human Lymphocyte Antigen Association in Ankylosing Spondylitis

A STUDY of human lymphocyte phenotypes in unrelated Caucasian individuals with ankylosing spondylitis has revealed a striking similarity in their antigenic pattern. The lymphocytes of fifty such patients, when tested against a panel of twenty-six different specific typing sera, using a two stage lym...

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Bibliographic Details
Published in:Nature (London) 1973-03, Vol.242 (5393), p.121-121
Main Authors: CAFFREY, MAEVE F. P, JAMES, D. C. O
Format: Article
Language:English
Subjects:
European Continental Ancestry Group
Histocompatibility Antigens - analysis
Humanities and Social Sciences
Humans
letter
Lymphocytes - immunology
multidisciplinary
Science
Science (multidisciplinary)
Spondylitis, Ankylosing - immunology
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Summary:A STUDY of human lymphocyte phenotypes in unrelated Caucasian individuals with ankylosing spondylitis has revealed a striking similarity in their antigenic pattern. The lymphocytes of fifty such patients, when tested against a panel of twenty-six different specific typing sera, using a two stage lymphocytotoxicity micro-method, were shown to have in common either the antigen HL-A27 (96%) or the antigen W5 (4%). This remarkably high frequency of the antigen HL-A27 compares with the incidence of 5–6% of this antigen in random Caucasian populations.
ISSN:0028-0836
1476-4687
DOI:10.1038/242121a0