Secondary chemotherapy of advanced breast cancer

A randomized, protocol study by the Cooperative Breast Cancer Group has demonstrated the efficacy of chlorambucil, prednisone, hydrocortisone, and triiodothyronine as secondary therapy for advanced female breast cancer. Objective regression rates of 20.7% for chlorambucil and prednisone combined, 11...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1973-03, Vol.31 (3), p.660-663
Main Authors: Goldenberg, Ira S., McMahan, C. A., Escher, George C., Volk, Herbert, Ansfield, Fred J., Olson, Kenneth B.
Format: Article
Language:English
Subjects:
Adult
Aged
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Chlorambucil - administration & dosage
Chlorambucil - therapeutic use
Female
Humans
Hydrocortisone - administration & dosage
Hydrocortisone - therapeutic use
Middle Aged
Neoplasm Metastasis
Prednisone - administration & dosage
Prednisone - therapeutic use
Remission, Spontaneous
Triiodothyronine - administration & dosage
Triiodothyronine - therapeutic use
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A randomized, protocol study by the Cooperative Breast Cancer Group has demonstrated the efficacy of chlorambucil, prednisone, hydrocortisone, and triiodothyronine as secondary therapy for advanced female breast cancer. Objective regression rates of 20.7% for chlorambucil and prednisone combined, 11.8% for hydrocortisone with triiodothyronine, and 9.8% for chlorambucil alone were defined. For the patient with advancing metastatic disease who has received initial hormonal therapy, it is recommended that further treatment with the combination of chlorambucil and prednisone be considered.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197303)31:3<660::AID-CNCR2820310326>3.0.CO;2-U