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Usefulness of oral beclometasone dipropionate in the treatment of active ulcerative colitis in clinical practice: the RECLICU Study

Beclometasone dipropionate (BDP) is a relatively new topically acting oral steroid to treat mild to moderately active ulcerative colitis (UC). We estimate that 20,000 patients have received oral BDP in Spain in the last two years. Our aim was to evaluate the efficacy and safety of oral BDP in clinic...

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Published in:Journal of Crohn's and colitis 2010-12, Vol.4 (6), p.629-636
Main Authors: Nunes, Tiago, Barreiro-de Acosta, Manuel, Nos, Pilar, Marin-Jiménez, Ignacio, Bermejo, Fernando, Ceballos, Daniel, Iglesias, Eva, Gomez-Senent, Silvia, Torres, Yolanda, Ponferrada, Angel, Arevalo, José A, Hernandez, Vicent, Calvet, Xavier, Ginard, Daniel, Monfort, David, Chaparro, Maria, Manceñido, Noemi, Domínguez-Antonaya, Mercedes, Villalón, César, Perez-Calle, José L, Muñoz, Carmen, Nuñez, Henar, Carpio, Daniel, Aramendiz, Roberto, Bujanda, Luis, Estrada-Oncins, Silvia, Hermida, Carlos, Barrio, Jesus, Casis, M Begoña, Dueñas-Sadornil, M Carmen, Fernández, Luis, Calvo-Cenizo, M Mar, Botella, Belen, de Francisco, Ruth, Ayala, Edgar, Sans, Miquel
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creator Nunes, Tiago
Barreiro-de Acosta, Manuel
Nos, Pilar
Marin-Jiménez, Ignacio
Bermejo, Fernando
Ceballos, Daniel
Iglesias, Eva
Gomez-Senent, Silvia
Torres, Yolanda
Ponferrada, Angel
Arevalo, José A
Hernandez, Vicent
Calvet, Xavier
Ginard, Daniel
Monfort, David
Chaparro, Maria
Manceñido, Noemi
Domínguez-Antonaya, Mercedes
Villalón, César
Perez-Calle, José L
Muñoz, Carmen
Nuñez, Henar
Carpio, Daniel
Aramendiz, Roberto
Bujanda, Luis
Estrada-Oncins, Silvia
Hermida, Carlos
Barrio, Jesus
Casis, M Begoña
Dueñas-Sadornil, M Carmen
Fernández, Luis
Calvo-Cenizo, M Mar
Botella, Belen
de Francisco, Ruth
Ayala, Edgar
Sans, Miquel
description Beclometasone dipropionate (BDP) is a relatively new topically acting oral steroid to treat mild to moderately active ulcerative colitis (UC). We estimate that 20,000 patients have received oral BDP in Spain in the last two years. Our aim was to evaluate the efficacy and safety of oral BDP in clinical practice. Retrospective and multicenter study that included 434 patients with active UC treated with BDP. The partial Mayo Clinic score (pMS, 0-9) was used to measure disease activity. Remission was defined as post-treatment pMS of 0 or 1; response as a decrease in pMS of 3 points or 2 points and >30%, and failure as lack of remission or response. BDP dose was 5 mg/day in 88% of patients and mean treatment duration was 6.2 weeks. BDP achieved remission in 44.4%, response in 22.3% and failed in 33.2% of patients. Mean pMS decreased from 4.9 ± 1.3 to 2.4 ± 2.3 (p
doi_str_mv 10.1016/j.crohns.2010.07.003
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identifier ISSN: 1873-9946
ispartof Journal of Crohn's and colitis, 2010-12, Vol.4 (6), p.629-636
issn 1873-9946
1876-4479
language eng
recordid cdi_proquest_miscellaneous_818639674
source Oxford Journals Online
subjects Administration, Oral
Adult
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Beclomethasone - administration & dosage
Beclomethasone - therapeutic use
Colitis, Ulcerative - drug therapy
Drug Administration Schedule
Female
Humans
Male
Remission Induction
Retrospective Studies
Severity of Illness Index
Treatment Outcome
title Usefulness of oral beclometasone dipropionate in the treatment of active ulcerative colitis in clinical practice: the RECLICU Study
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