J-curve revisited: an analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial

Aim In patients with coronary artery disease (CAD), a J-curve relationship has been reported between blood pressure (BP) and future cardiovascular events. However, this is controversial. The purpose of the study was to determine the relationship between on-treatment BP and cardiovascular outcomes in...

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Bibliographic Details
Published in:European heart journal 2010-12, Vol.31 (23), p.2897-2908
Main Authors: Bangalore, Sripal, Messerli, Franz H., Wun, Chuan-Chuan, Zuckerman, Andrea L., DeMicco, David, Kostis, John B., LaRosa, John C.
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive Agents - administration & dosage
Atorvastatin Calcium
Biological and medical sciences
Blood pressure
Blood Pressure - physiology
Cardiology. Vascular system
Coronary Disease - etiology
Coronary Disease - mortality
Coronary Disease - physiopathology
Dose-Response Relationship, Drug
Double-Blind Method
Female
Heart Arrest - etiology
Heart Arrest - mortality
Heart Arrest - physiopathology
Heptanoic Acids - administration & dosage
Humans
Hypertension - drug therapy
Hypertension - mortality
Hypertension - physiopathology
J-Curve
Male
Medical sciences
Middle Aged
Myocardial Infarction - etiology
Myocardial Infarction - mortality
Myocardial Infarction - physiopathology
Pyrroles - administration & dosage
Risk Factors
Stroke - etiology
Stroke - mortality
Stroke - physiopathology
TNT trial
Treatment Outcome
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Summary:Aim In patients with coronary artery disease (CAD), a J-curve relationship has been reported between blood pressure (BP) and future cardiovascular events. However, this is controversial. The purpose of the study was to determine the relationship between on-treatment BP and cardiovascular outcomes in patients with CAD. Methods and results We evaluated 10 001 patients with CAD and a low-density lipoprotein (LDL) cholesterol level
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehq328