Prognosticators in thigh soft tissue sarcomas

Background In sarcoma patients the roles of smoking history, family cancer history, and leukoreduced blood transfusions have not been studied and the effect of preoperative radiation on blood loss has not been examined. Methods Seventy‐seven patients with non‐metastatic and non‐recurrent thigh sarco...

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Published in:Journal of surgical oncology 2011-01, Vol.103 (1), p.85-91
Main Authors: Newcomer, Anne E., Dylinski, Diane, Rubin, Brian P., Joyce, Michael J., Hoeltge, Gerald, Bershadsky, Boris, Lietman, Steven A.
Format: Article
Language:English
Subjects:
cancer
Family Health
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Radiotherapy, Adjuvant - adverse effects
Retrospective Studies
Risk Factors
sarcoma
Sarcoma - mortality
Sarcoma - pathology
Sarcoma - therapy
smoking
Smoking - adverse effects
Soft Tissue Neoplasms - mortality
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - therapy
Thigh
transfusion
Transfusion Reaction
Treatment Outcome
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Summary:Background In sarcoma patients the roles of smoking history, family cancer history, and leukoreduced blood transfusions have not been studied and the effect of preoperative radiation on blood loss has not been examined. Methods Seventy‐seven patients with non‐metastatic and non‐recurrent thigh sarcomas surgically treated at the Cleveland Clinic were identified. Among patient variables studied were: close family history of cancer, perioperative transfusion history, smoking history, and radiation history. Median follow‐up for the survivors was 3.2 years. Results We found that tumor grade, transfusion >3 U (P = 0.022), and pre‐ or post‐operative radiation therapy (P = 0.041) were risk factors for distant metastasis. Tumor grade (P = 0.008), positive smoking history (P = 0.039), and >3 U of non‐leukoreduced blood transfused (P = 0.037) were risk factors for death of any‐cause. Close family history of cancer correlated with having a grade 3 sarcoma (P = 0.044). Neoadjuvant radiotherapy correlated with >3 U of blood transfused (P = 0.001) and biopsy performed at the treating institution led to a significant decrease in rate of recurrence (P = 0.016). Conclusions We present novel findings in terms of transfusions, family history of cancer and site of initial biopsy in sarcoma patients. J. Surg. Oncol. 2011;103:85–91. © 2010 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21763