INCIDENCE AND RISK FACTORS OF TRANSPLANT RENAL ARTERY STENOSIS IN LIVING UNRELATED DONOR RENAL TRANSPLANTATION

SUMMARY Background: This study was designed to evaluate the incidence and risk factors of transplant renal artery stenosis (TRAS) among living donor unrelated kidney recipients. Patients and methods: Three hundred and sixty kidney consecutive transplant recipients were included in this retrospective...

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Published in:Journal of renal care 2010-09, Vol.36 (3), p.149-152
Main Authors: Kamali, Koosha, Abbasi, Mohammad Amin, Behzadi, Ashkan Heshmatzade, Mortazavi, Ahmad, Bastani, Bahar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Cytomegalovirus infection
Cytomegalovirus Infections - epidemiology
Delayed graft function
Delayed Graft Function - epidemiology
Female
Humans
Incidence
Iran - epidemiology
Kidney Transplantation - adverse effects
Living Donors
Male
Middle Aged
Multivariate Analysis
Nursing
Renal Artery Obstruction - epidemiology
Renal Artery Obstruction - etiology
Retrospective Studies
Risk Factors
Transplant renal artery stenosis
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Summary:SUMMARY Background: This study was designed to evaluate the incidence and risk factors of transplant renal artery stenosis (TRAS) among living donor unrelated kidney recipients. Patients and methods: Three hundred and sixty kidney consecutive transplant recipients were included in this retrospective cohort study. Informed written consent was obtained, only TRAS occurring three months after transplantation were considered. After five‐year follow up, TRAS was established in 6.6% (24 patients) of patients. Results: Mean ± SD age of recipients was 39.8 ± 14.9 years old (range 16–77). Upon multivariate analysis recipient age >50 (RR = 2.9, CI 95%: 1.33–2.93, p = 0.008), recipient BMI >30 (kg/m2) (RR: 7.97, CI 95%: 3.44–18.46, p < 0.001), retransplantation (RR = 4.88, CI 95%: 2.21–10.77, p < 0.001), cytomegalovirus (CMV) infection and delayed graft function (DGF) (RR: 4.29, CI 95%: 3.12–13.79, p = 0.01) appeared to be independently associated with TRAS. Positive CMV‐antibody was more frequent in recipients with TRAS (95.83% vs. 70.8%, p = 0.04) but all of them were HCV‐antibody negative. Other variables as discussed were similar between two groups. Conclusion: High recipient age, BMI > 30, hyper trigelyceridaemia, previous transplantation, CMV infection and DGF are shown to be risk factors for TRAS.
ISSN:1755-6678
1755-6686
DOI:10.1111/j.1755-6686.2010.00188.x