Impaired Learning and Decreased Cortical Norepinephrine after Bilateral Locus Coeruleus Lesions

Bilateral lesions of the nucleus locus coeruleus in rats deplete the cerebral cortex of norepinephrine and significantly diminish the rate of increase of running for food reward in a simple L-shaped runway. As assessed in this situation, learning was absent in those rats with the most complete ablat...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-08, Vol.181 (4100), p.682-684
Main Authors: Anlezark, G. M., Crow, T. J., Greenway, A. P.
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Brain Chemistry
Brain Stem
Cerebellum
Cerebral cortex
Cerebral Cortex - analysis
Cerebral Ventricles - physiology
Denervation
Electrodes
Fluorine
Learning
Lesions
Liver
Locus coeruleus
Male
Memory
Motor Activity
Norepinephrine
Norepinephrine - analysis
Rats
Reward
Waveforms
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Description
Summary:Bilateral lesions of the nucleus locus coeruleus in rats deplete the cerebral cortex of norepinephrine and significantly diminish the rate of increase of running for food reward in a simple L-shaped runway. As assessed in this situation, learning was absent in those rats with the most complete ablations of the locus coeruleus, although these rats showed normal weight gain and normal motor and exploratory activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.181.4100.682