Infusion of 2-Deoxy-D-Glucose into the Hepatic-Portal System Causes Eating: Evidence for Peripheral Glucoreceptors

Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest th...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-08, Vol.181 (4102), p.858-860
Main Authors: Novin, Donald, VanderWeele, Dennis A., Rezek, Milan
Format: Article
Language:English
Subjects:
Animals
Appetite Regulation
Brain
Catheterization
Food consumption
Food intake
Glucose - administration & dosage
Glucose - metabolism
Hunger
Jugular vein
Jugular Veins
Liver
Liver - innervation
Liver - metabolism
Portal System
Rabbits
Receptors
Receptors, Drug
Sleep
Stomach
Vagotomy
Vagus Nerve - physiology
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Description
Summary:Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest the existence of vagally mediated peripheral glucoreceptors important in the initiation of food intake.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.181.4102.858