Spontaneous Whole Brain Slow Potential Changes during Recovery from Experimental Neurosurgery

Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motil...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-09, Vol.181 (4105), p.1176-1178
Main Authors: Irwin, Don A., Criswell, Hugh E., Kakolewski, Jan W.
Format: Article
Language:English
Subjects:
Amplifiers
Animals
Brain - physiology
Brain - surgery
Cerebral Cortex - physiology
Cortical Spreading Depression
Depressive disorders
Electrodes
Electrodes, Implanted
Embryos
Hypothalamus
Hypothalamus - physiology
Implants
Kidneys
Male
Membrane Potentials
Organ culture techniques
Potassium
Rats
Stereotaxic Techniques
Waveforms
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Description
Summary:Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motility. The method used in this study provides a tool for evaluating recovery from neurosurgical trauma or other brain injuries, and for testing procedures that facilitate or impede this process.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.181.4105.1176