Phenols as Inhibitors of the Heparin Co-factor of Plasma

PHENOLS counteract the antithrombic activity of plasma and serum 1 . The antithrombic activity is present in a protein fraction which also contains the co-factor required for the anticoagulant effect of heparin 2 . The antithrombic and the heparin co-factor activity are present in the α-globulin fra...

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Bibliographic Details
Published in:Nature (London) 1957-11, Vol.180 (4593), p.990-990
Main Authors: FANTL, P, MARR, A. G. M
Format: Article
Language:English
Subjects:
Heparin
Heparin Antagonists
Humanities and Social Sciences
Humans
letter
Lipase
multidisciplinary
Old Medline
Phenols - pharmacology
Plasma
Science
Science (multidisciplinary)
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Summary:PHENOLS counteract the antithrombic activity of plasma and serum 1 . The antithrombic activity is present in a protein fraction which also contains the co-factor required for the anticoagulant effect of heparin 2 . The antithrombic and the heparin co-factor activity are present in the α-globulin fraction of human plasma 3 . It was therefore of interest to test the influence of phenols on heparin activity in plasma.
ISSN:0028-0836
1476-4687
DOI:10.1038/180990a0