Independent Segregation of the H-2 Locus and the Locus for Responsiveness to Histamine-Sensitizing Factor

The inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli was examined in (SWR/J x CBA/J)F1x CBA/J backcross mice. We found that about half of the backcross mice inherited this responsiveness in both sexes. There was no linkage between the inheritance of responsiveness t...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1973-09, Vol.70 (9), p.2500-2501
Main Authors: Ovary, Zoltan, Vris, Thomas W., De Szalay, Csaba, Vaz, Nelson M., Iritani, Chika A.
Format: Article
Language:English
Subjects:
Alleles
Allergies
Animals
Biological Sciences: Genetics
Bordetella pertussis
Female
Genetic inheritance
Genetic Linkage
Genetic loci
Histamine
Histamines
Histocompatibility
Hypersensitivity, Immediate - genetics
Inbred strains
Male
Mice
Mice, Inbred CBA
Mice, Inbred Strains
Mortality
Pertussis Vaccine
Whooping cough
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Summary:The inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli was examined in (SWR/J x CBA/J)F1x CBA/J backcross mice. We found that about half of the backcross mice inherited this responsiveness in both sexes. There was no linkage between the inheritance of responsiveness to histamine-sensitizing factor and the H-2qlocus from the sensitive SW/J progenitor.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.70.9.2500