A preliminary study on the action of cassava on thyroid iodine metabolism in rats

1. The ingestion of cassava (Manihot esculenta Crantz) by rats increased the plasma thiocyanate concentration and reduced the thyroid iodine content and the plasma protein-bound iodine. 2. Administration of increasing doses of thiocyanate raised the plasma thiocyanate concentration and reduced the t...

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Bibliographic Details
Published in:British journal of nutrition 1973-11, Vol.30 (3), p.511-517
Main Authors: Van Der velden, M, Kinthaert, J, Orts, S., Ermans, A. M
Format: Article
Language:English
Subjects:
Animals
Cyanides - metabolism
Democratic Republic of the Congo
Diet
General Nutrition
Glucuronidase
Goiter, Endemic - etiology
Iodine - metabolism
Male
Manihot
Rats
Thiocyanates - blood
Thyroid Function Tests
Thyroid Gland - metabolism
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Summary:1. The ingestion of cassava (Manihot esculenta Crantz) by rats increased the plasma thiocyanate concentration and reduced the thyroid iodine content and the plasma protein-bound iodine. 2. Administration of increasing doses of thiocyanate raised the plasma thiocyanate concentration and reduced the thyroid iodine content and the plasma protein-bound iodine. 3. In producing these effects, the daily ingestion of 10 g cassava root containing 1·6 mg cyanide was approximately equivalent to a daily intake of about 1–2 mg thiocyanate. 4. These results suggest that the antithyroid action of cassava is the result of the production of thiocyanate by the rat from cyanide arising from the cyanogenic glucosides present in this food.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19730057