Pathogenesis of Feline Viral Fibrosarcomas: Dose and Age Effects

The effects of virus dose and host age at the time of inoculation were studied in cats. Twenty-eight neonatal kittens were inoculated with tenfold serial dilutions of a pooled cell-free preparation of ST-feline sarcoma virus to examine the effects of virus dose on subsequent tumorigenesis. Similarly...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1973-09, Vol.51 (3), p.793-798
Main Authors: Snyder, S. P., Dungworth, D. L.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Cats
Cell-Free System
Fibrosarcoma - etiology
Microscopy, Electron
Neoplasm Regression, Spontaneous
Retroviridae
Sarcoma, Experimental - etiology
Time Factors
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Summary:The effects of virus dose and host age at the time of inoculation were studied in cats. Twenty-eight neonatal kittens were inoculated with tenfold serial dilutions of a pooled cell-free preparation of ST-feline sarcoma virus to examine the effects of virus dose on subsequent tumorigenesis. Similarly, age effects were studied in 20 cats ranging from neonates to 1-year-olds. Fibrosacromas induced in younger animals and in those given the higher doses of inoculum had shorter latent periods, enlarged rapidly, contained more virus particles on electron microscopy, attained greater size, and resulted in the animals' deaths. Conversely, older animals and those given lower doses of inoculum developed slowly enlarging tumors after a prolonged latent period; these fibrosarcomas contained fewer virus particles and tended to regress.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/51.3.793