Solid phase synthesis of [1-deamino,4-valine]-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects

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Bibliographic Details
Published in:Journal of medicinal chemistry 1973-09, Vol.16 (9), p.975-978
Main Authors: Manning, Maurice, Balaspiri, Lajos, Acosta, Margot, Sawyer, Wilbur H
Format: Article
Language:English
Subjects:
Animals
Arginine - chemical synthesis
Arginine - pharmacology
Blood Pressure - drug effects
Deamination
Diabetes Insipidus - urine
Diuresis - drug effects
Female
Muscle Contraction - drug effects
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Uterus - drug effects
Valine - chemical synthesis
Valine - pharmacology
Vasopressins - chemical synthesis
Vasopressins - pharmacology
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00267a004