Clinical Significance of Plasma Osteopontin Level in Egyptian Patients with Hepatitis C Virus-related Hepatocellular Carcinoma

Background and Aims Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies worldwide. Osteopontin (OPN) is a secreted glycoprotein frequently associated with various tumors. This study aimed to investigate the clinical usefulness of plasma OPN level as a biomarker for H...

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Bibliographic Details
Published in:Archives of medical research 2010-10, Vol.41 (7), p.541-547
Main Authors: El-Din Bessa, Sahar Saad, Elwan, Nadia Mohamed, Suliman, Ghada Abdul Moemen, El-Shourbagy, Safinaz Hamdy
Format: Article
Language:English
Subjects:
Aged
Alpha-fetoprotein
alpha-Fetoproteins - metabolism
Biomarkers - blood
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - virology
Diagnosis, Differential
Egypt
Female
Hepacivirus
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C virus
Hepatocellular carcinoma
Humans
Internal Medicine
Liver Neoplasms - blood
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver Neoplasms - virology
Male
Middle Aged
Osteopontin
Osteopontin - blood
Prognosis
ROC Curve
Sensitivity and Specificity
Tumor markers
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Summary:Background and Aims Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies worldwide. Osteopontin (OPN) is a secreted glycoprotein frequently associated with various tumors. This study aimed to investigate the clinical usefulness of plasma OPN level as a biomarker for HCC among high-risk patients compared to alpha-fetoprotein (AFP) and to evaluate its relationship with clinicopathological features of HCC patients. Methods Plasma levels of OPN and AFP were measured in 60 Egyptian patients with hepatitis C virus-related liver cirrhosis (30 with HCC, 30 without HCC) and 20 healthy controls. Results Plasma OPN levels in cirrhotic patients with HCC were significantly higher than in those without HCC and controls ( p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2010.10.007