Dual Grafts Live Donor Liver Transplantation for Acute-on-Chronic Hepatitis B Liver Failure

Abstract Objective This study reports the preliminary experience of dual grafts living donor liver transplantation (LDLT) for patients with acute-on-chronic liver failure (AoCLF) caused by hepatitis B. Methods Two patients who demonstrated acute-on-chronic hepatitis B liver failure and portal hypert...

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Bibliographic Details
Published in:Transplantation proceedings 2010-12, Vol.42 (10), p.4552-4554
Main Authors: Chen, Z, Zeng, Y, Wen, T.F, Gong, S, Zhao, J.C, Li, B, Wang, W.T, Xu, M.Q, Yang, J, Wu, H, Yan, L.N
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Chronic Disease
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hepatitis B - physiopathology
Hepatitis B - prevention & control
Hepatitis B - surgery
Human viral diseases
Humans
Immunosuppressive Agents - administration & dosage
Infectious diseases
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Living Donors
Medical sciences
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tissue, organ and graft immunology
Viral diseases
Viral hepatitis
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Summary:Abstract Objective This study reports the preliminary experience of dual grafts living donor liver transplantation (LDLT) for patients with acute-on-chronic liver failure (AoCLF) caused by hepatitis B. Methods Two patients who demonstrated acute-on-chronic hepatitis B liver failure and portal hypertension with Model for End-Stage Liver Disease (MELD) scores of 42 and 37, respectively, underwent dual LDLT grafts including one right lobe without a middle hepatic vein and one left lobe because the graft-to-recipient body weight ratio of the right lobe grafts were 0.53% and 0.66%. The donors and the recipients have been followed for over 1 year. Results Mortality and operative complications were not observed in the donors or recipients. At present, the donors and recipients have returned to their daily routine. No prisoners or organs from prisoners were used to obtain these data. Conclusion Dual LDLT grafts including one right lobe without the middle hepatic vein and one left lobe may be a possible therapeutic option for subjects with acute-on-chronic hepatitis B-induced liver failure.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.09.172