Impact of Cold Ischemia on Renal Transplant Outcomes Following Donation After Cardiac Death

Abstract Donation after cardiac death (DCD) provides grafts in renal transplantation but is associated with increased early graft dysfunction. Cold ischemia time (CIT) is a factor that is thought to affect outcomes in renal transplantation. We sought to assess the impact of the length of CIT among o...

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Bibliographic Details
Published in:Transplantation proceedings 2010-12, Vol.42 (10), p.3951-3953
Main Authors: Pine, J.K, Goldsmith, P.J, Ridgway, D.M, Baker, R, Newstead, C.G, Pollard, S.G, Menon, K.V, Ahmad, N, Attia, M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cryopreservation
Death
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Survival
Humans
Ischemia
Kidney - blood supply
Kidney Transplantation
Male
Medical sciences
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Time Factors
Tissue and Organ Procurement
Tissue, organ and graft immunology
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Summary:Abstract Donation after cardiac death (DCD) provides grafts in renal transplantation but is associated with increased early graft dysfunction. Cold ischemia time (CIT) is a factor that is thought to affect outcomes in renal transplantation. We sought to assess the impact of the length of CIT among our DCD cohort of renal transplants performed between April 2002 and December 2009. Since the median CIT was 15.5 hours, we formed two groups CIT < 15.5 ( n = 100) and CIT > 15.5 hr ( n = 98). We demonstrated an increased incidence of DGF among the extended CIT group, but the long outcomes and the mean graft function were otherwise comparable. In conclusion, CIT affects early graft function; every effort should be made to minimize it in renal transplantation using DCD kidneys.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.10.004