Impact of Cold Ischemia on Renal Transplant Outcomes Following Donation After Cardiac Death

• Published in: Transplantation proceedings 2010-12, Vol.42 (10), p.3951-3953
• Main Authors: Pine, J.K, Goldsmith, P.J, Ridgway, D.M, Baker, R, Newstead, C.G, Pollard, S.G, Menon, K.V, Ahmad, N, Attia, M
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cryopreservation; Death; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Survival; Humans; Ischemia; Kidney - blood supply; Kidney Transplantation; Male; Medical sciences; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Time Factors; Tissue and Organ Procurement; Tissue, organ and graft immunology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.10.004

Abstract Donation after cardiac death (DCD) provides grafts in renal transplantation but is associated with increased early graft dysfunction. Cold ischemia time (CIT) is a factor that is thought to affect outcomes in renal transplantation. We sought to assess the impact of the length of CIT among our DCD cohort of renal transplants performed between April 2002 and December 2009. Since the median CIT was 15.5 hours, we formed two groups CIT < 15.5 ( n = 100) and CIT > 15.5 hr ( n = 98). We demonstrated an increased incidence of DGF among the extended CIT group, but the long outcomes and the mean graft function were otherwise comparable. In conclusion, CIT affects early graft function; every effort should be made to minimize it in renal transplantation using DCD kidneys.