Dose-related effects of isoprenaline on the distribution of cardiac output and myocardial blood flow in conscious monkeys

Intravenous isoprenaline infusions in conscious monkeys gave dose-related increased blood flow and falls in resistance to heart, skeletal muscle, intestines, adipose tissue, and bone. The fraction of cardiac output to brain, kidney, skin, and pancreas fell. There was a small but statistically signif...

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Bibliographic Details
Published in:Cardiovascular research 1973-09, Vol.7 (5), p.664-669
Main Authors: HOFFBRAND, BARRY I., FORSYTH, RALPH P., MELMON, KENNETH L.
Format: Article
Language:English
Subjects:
Adipose Tissue - blood supply
Animals
Blood Pressure - drug effects
Bone and Bones - blood supply
Cardiac Output - drug effects
Cerebrovascular Circulation - drug effects
Coronary Circulation - drug effects
Dose-Response Relationship, Drug
Haplorhini
Heart Rate - drug effects
Injections, Intravenous
Intestines - blood supply
Isoproterenol - administration & dosage
Isoproterenol - pharmacology
Kidney - blood supply
Macaca
Male
Muscles - blood supply
Pancreas - blood supply
Skin - blood supply
Vascular Resistance - drug effects
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Summary:Intravenous isoprenaline infusions in conscious monkeys gave dose-related increased blood flow and falls in resistance to heart, skeletal muscle, intestines, adipose tissue, and bone. The fraction of cardiac output to brain, kidney, skin, and pancreas fell. There was a small but statistically significant increase in the fraction of myocardial blood flow to the atria with a fall in that to the intraventricular septum.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/7.5.664