Effects of Trimethoprim and Sulfisoxazole Alone and in Combination on Murine Toxoplasmosis

Trimethoprim and sulfisoxazole, alone and in combination, were administered in drinking water or by injection to mice inoculated with Toxoplasma gondii (RH strain). The toxoplasma infections were unaffected by any of the treatment schedules. On the basis of these experiences, it would appear that tr...

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Bibliographic Details
Published in:The Journal of infectious diseases 1973-11, Vol.128 (Supplement-3), p.S774-S777
Main Authors: Neu, Harold C., Feldman, Harry A.
Format: Article
Language:English
Subjects:
Animals
Dosage
Female
Infections
Inoculation
Inoculum
Male
Mice
Parasites
Potable water
Section VII. Clinical Experience: Other Infections
Sulfisoxazole - administration & dosage
Sulfisoxazole - therapeutic use
Sulfonamides
Toxoplasmosis
Toxoplasmosis - drug therapy
Trimethoprim - administration & dosage
Trimethoprim - therapeutic use
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Summary:Trimethoprim and sulfisoxazole, alone and in combination, were administered in drinking water or by injection to mice inoculated with Toxoplasma gondii (RH strain). The toxoplasma infections were unaffected by any of the treatment schedules. On the basis of these experiences, it would appear that trimethoprim and sulfisoxazole, alone or in combination, are inappropriate for the treatment of human toxoplasmosis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/128.Supplement_3.S774