Intestinal Calcium Binding Protein in the Diabetic Rat

A SPECIFIC duodenal calcium binding protein (CaBP) has been implicated in calcium absorption in many animal species 1 and adaptation of duodenal adsorption to increased calcium intake is accompanied by its increase. Vitamin D deficiency depletes and repletion restores CaBP with corresponding changes...

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Bibliographic Details
Published in:Nature (London) 1973-10, Vol.245 (5424), p.327-328
Main Authors: SCHNEIDER, LOUIS E., WILSON, HELEN D., SCHEDL, HAROLD P.
Format: Article
Language:English
Subjects:
Acrylamides
Animals
Calcium - metabolism
Chromatography, Gel
Diabetes Mellitus, Experimental - metabolism
Duodenum - analysis
Duodenum - metabolism
Electrophoresis, Polyacrylamide Gel
Humanities and Social Sciences
Intestinal Mucosa - analysis
Intestinal Mucosa - metabolism
letter
Male
multidisciplinary
Protein Binding
Proteins - analysis
Rats
Science
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Summary:A SPECIFIC duodenal calcium binding protein (CaBP) has been implicated in calcium absorption in many animal species 1 and adaptation of duodenal adsorption to increased calcium intake is accompanied by its increase. Vitamin D deficiency depletes and repletion restores CaBP with corresponding changes in duodenal absorption. The exact role of CaBP in calcium absorption has, however, not yet been defined. We studied calcium absorption in the diabetic rat, in which model system previous studies have shown enhanced carbohydrate and amino acid absorption 2,3 , and found decreased duodenal but normal ileal absorption 4 . Since CaBP may be important in duodenal calcium absorption, we report here studies of CaBP in rats made diabetic with alloxan.
ISSN:0028-0836
1476-4687
DOI:10.1038/245327a0