Vitamin D-induced Synthesis of mRNA for Calcium-binding Protein

THE discovery that vitamin D must first be converted into the metabolites 25-hydroxycholecalciferol 1 (25 OH-D 3 ) and 1,25-dihydroxycholecalciferol 2 (1,25(OH) 2 -D 3 ) before calcium absorption across the small intestine is enhanced has radically changed existing ideas as to the mode of action of...

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Bibliographic Details
Published in:Nature (London) 1973-11, Vol.246 (5428), p.100-101
Main Authors: EMTAGE, J. S., LAWSON, D. E. M., KODICEK, E.
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Carbon Radioisotopes
Cell Fractionation
Cell-Free System
Chickens
Cholecalciferol - pharmacology
Humanities and Social Sciences
Immunoassay
Intestinal Mucosa - cytology
Intestinal Mucosa - metabolism
letter
Leucine - metabolism
Liver - cytology
Liver - metabolism
multidisciplinary
Polyribosomes - metabolism
Protein Binding
Protein Biosynthesis - drug effects
Proteins - analysis
Reticulocytes - metabolism
RNA, Messenger - biosynthesis
Science
Science (multidisciplinary)
Transcription, Genetic - drug effects
Tritium
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Summary:THE discovery that vitamin D must first be converted into the metabolites 25-hydroxycholecalciferol 1 (25 OH-D 3 ) and 1,25-dihydroxycholecalciferol 2 (1,25(OH) 2 -D 3 ) before calcium absorption across the small intestine is enhanced has radically changed existing ideas as to the mode of action of vitamin D. Indeed, it is now well established that the most active metabolite of vitamin D for calcium absorption, 1,25(OH) 2 -D 3 , is produced solely by the kidney 3 and that its production and secretion are under very fine endocrine control. This finding, together with the observation that 1,25(OH) 2 -D 3 is specifically located in the nucleus of the target cell 4 and the apparent involvement of RNA and protein synthesis 5–7 in the intestinal action of vitamin D, provide the basis of the proposal that 1,25(OH) 2 -D 3 can be classed as a steroid hormone.
ISSN:0028-0836
1476-4687
DOI:10.1038/246100a0