Effect of an intravenous sodium chloride load on renal hemodynamics and electrolyte excretion in essential hypertension

Excretion of infused sodium, chloride, and water increased proportionately in patients with progressively more severe grades of hypertension and of increased renal vascular resistance. These relationships held so long as renal plasma flow and glomerular filtration rate were not greatly impaired. The...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1958-04, Vol.17 (4, Part 2), p.750-760
Main Authors: COTTIER, P T, WELLER, J M, HOOBLER, S W
Format: Article
Language:English
Subjects:
Electrolytes - urine
Essential Hypertension
Hemodynamics
Hypertension - physiology
Kidney - physiology
Old Medline
Sodium Chloride - pharmacology
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Summary:Excretion of infused sodium, chloride, and water increased proportionately in patients with progressively more severe grades of hypertension and of increased renal vascular resistance. These relationships held so long as renal plasma flow and glomerular filtration rate were not greatly impaired. The abnormality was characterized by increased renal tubular rejection of sodium, chloride and water.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.17.4.750