Differential contributions of objective memory and mood to subjective memory complaints in refractory focal epilepsy

Abstract People with epilepsy frequently present with bitter memory complaints. Previous research variously attributes this to symptoms of mood disturbance or objective memory deficits. To investigate the influence of the epileptogenic region on this variability, we examined interrelationships betwe...

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Bibliographic Details
Published in:Epilepsy & behavior 2010-11, Vol.19 (3), p.359-364
Main Authors: Rayner, Genevieve, Wrench, Joanne M, Wilson, Sarah J
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Control group
Epilepsies, Partial - complications
Female
Focal epilepsy
Humans
Male
Memory - classification
Memory - physiology
Memory Disorders - diagnosis
Memory Disorders - etiology
Mesial temporal lobe function
Middle Aged
Mood
Mood Disorders - diagnosis
Mood Disorders - etiology
Neurology
Neuropsychological Tests
Objective memory disorders
Regression Analysis
Subjective memory complaints
Surveys and Questionnaires
Young Adult
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Summary:Abstract People with epilepsy frequently present with bitter memory complaints. Previous research variously attributes this to symptoms of mood disturbance or objective memory deficits. To investigate the influence of the epileptogenic region on this variability, we examined interrelationships between mood, objective memory, and memory complaints in a sample of patients with refractory focal epilepsy and controls ( N = 96). Patients had either mesial temporal (MT, n = 39) or non mesial-temporal (NMT, n = 21) foci. In contrast to controls ( n = 36), both patient groups were highly concerned about their memory ( P < 0.001) and were more likely to have a history of depression ( P = 0.005). Multiple regression showed that objective memory dysfunction and current depressive symptoms predicted the memory complaints of patients with MT epilepsy ( P = 0.005), whereas a history of depression predicted the complaints of patients with NMT epilepsy ( P = 0.008). These findings suggest that patients have concerns about their memory underpinned by distinct psychological and neurobiological factors depending on the location of their epileptogenic focus.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2010.07.019