Human adipose-derived stem cells: current challenges and clinical perspectives

Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2010-09, Vol.85 (5), p.647-656
Main Authors: Yarak, Samira, Okamoto, Oswaldo Keith
Format: Article
Language:English
Subjects:
Adipogenesis - physiology
Adipose Tissue - cytology
Adult Stem Cells - cytology
Cell Differentiation
Cell Proliferation
Humans
Mesenchymal Stem Cells - cytology
Regenerative Medicine
Tissue and Organ Harvesting - methods
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Summary:Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells, but have some advantages including harvesting through a less invasive surgical procedure. Moreover, adipose tissue-derived stem cells have the potential to differentiate into cells of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, as well as cells of non-mesodermal lineage, such as hepatocytes, pancreatic endocrine cells, neurons, cardiomyocytes, and vascular endothelial cells. There are, however, inconsistencies in the scientific literature regarding methods for harvesting adipose tissue and for isolating, characterizing and handling adipose tissue-derived stem cells. Future clinical applications of adipose tissue-derived stem cells rely on more defined and widespread methods for obtaining cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem cell research are discussed with emphasis on strategies designed for future applications in regenerative medicine and possible challenges along the way.
ISSN:1806-4841
DOI:10.1590/s0365-05962010000500008