The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats

Abstract Deficits in memory function have been observed in pentylentetrazole (PTZ)-kindled rats. In the present study we examined the effects of atorvastatin ((3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitor) on PTZ kindling and related memory deficits in rats trained with the pa...

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Bibliographic Details
Published in:Epilepsy & behavior 2010-11, Vol.19 (3), p.284-289
Main Authors: Üzüm, Gülay, Akgün-Dar, Kadriye, Aksu, Uğur
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Anticholesteremic Agents - therapeutic use
Atorvastatin
Atorvastatin Calcium
Avoidance Learning - drug effects
Disease Susceptibility - chemically induced
Disease Susceptibility - physiopathology
Electroencephalography
Epilepsy
Heptanoic Acids - therapeutic use
Kindling
Kindling, Neurologic - drug effects
Kindling, Neurologic - physiology
Male
Memory
Memory Disorders - drug therapy
Memory Disorders - etiology
Neurology
Passive avoidance
Pentylenetetrazole
Pyrroles - therapeutic use
Rats
Rats, Wistar
Reaction Time
Seizures - chemically induced
Seizures - complications
Seizures - drug therapy
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Summary:Abstract Deficits in memory function have been observed in pentylentetrazole (PTZ)-kindled rats. In the present study we examined the effects of atorvastatin ((3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitor) on PTZ kindling and related memory deficits in rats trained with the passive avoidance test. Subconvulsive PTZ doses rendered a gradual increase in seizure activity. PTZ kindling caused long-term memory to deteriorate. Atorvastatin per se and in PTZ-kindled rats improved learning and memory functions. It also prolonged latency (time to appearance of spike potentials) and diminished the amplitude and frequency of spike potentials, which indicate epileptic discharges. These novel findings suggest that the favorable effect of the atorvastatin on memory deficits provoked by PTZ kindling might be of clinical utility.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2010.07.024