C‐MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C‐MYC

Anaplastic lymphoma kinase (ALK) positive anaplastic large cell lymphoma (ALCL) is usually associated with a favorable prognosis. We describe an 11-year-old girl patient with ALK positive ALCL bearing t(2;5)(p23;q35) and t(8;17)(q24;q25) translocations who had an aggressive clinical course despite v...

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Bibliographic Details
Published in:American journal of hematology 2011-01, Vol.86 (1), p.75-78
Main Authors: Moritake, Hiroshi, Shimonodan, Hidemi, Marutsuka, Kousuke, Kamimura, Sachiyo, Kojima, Hitomi, Nunoi, Hiroyuki
Format: Article
Language:English
Subjects:
Child
Chromosomes, Human, Pair 17
Female
Gene Rearrangement
Genes, myc
Hematology
Humans
Lymphoma, Large-Cell, Anaplastic - enzymology
Lymphoma, Large-Cell, Anaplastic - genetics
Lymphoma, Large-Cell, Anaplastic - pathology
Oncogene Proteins, Fusion - genetics
Phenotype
Protein-Tyrosine Kinases - biosynthesis
Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases
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Summary:Anaplastic lymphoma kinase (ALK) positive anaplastic large cell lymphoma (ALCL) is usually associated with a favorable prognosis. We describe an 11-year-old girl patient with ALK positive ALCL bearing t(2;5)(p23;q35) and t(8;17)(q24;q25) translocations who had an aggressive clinical course despite various combinations of intensive chemotherapy. Southern blot analysis identified C-MYC rearrangement. Immunohistochemistry and Northern and Western blot analyses revealed cmyc overexpression. A new fusion between ALO17 (ALK lymphoma oligomerization partner on chromosome 17) and C-MYC was identified by the 50-rapid amplification of cDNA ends. This new fusion may have possibly provoked the poor prognosis in this patient with ALK positive ALCL, and C-MYC rearrangement may indicate poor prognosis in ALCL.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.21887