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Role of Oral Hygiene in Inflammatory Bowel Disease
Background The ‘hygiene hypothesis' suggests that a reduction in the microbial exposure due to improved health measures has contributed to an immunological imbalance in the intestine and increased the incidence of autoimmune diseases such as inflammatory bowel diseases (IBD). Accordingly, we in...
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| Published in: | Digestive diseases and sciences 2011, Vol.56 (1), p.170-175 |
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| creator | Singhal, Shashideep Dian, Delia Keshavarzian, Ali Fogg, Louis Fields, Jeremy Z Farhadi, Ashkan |
| description | Background The ‘hygiene hypothesis' suggests that a reduction in the microbial exposure due to improved health measures has contributed to an immunological imbalance in the intestine and increased the incidence of autoimmune diseases such as inflammatory bowel diseases (IBD). Accordingly, we investigated associations between oral hygiene practices and IBD. Methods We developed and administered a multiple choice questionnaire to evaluate oral hygiene and dental care practices of 137 subjects (83 with IBD and 54 healthy controls). Results Of the 83 IBD cases, 31% had ulcerative colitis and 69% had Crohn's disease. For subjects with IBD, the frequency of brushing at disease onset was significantly higher than in controls (P = 0.005). Also, the frequency of use of dental floss and breath freshener at disease onset was significantly higher in IBD patients (P = 0.005 and |
| doi_str_mv | 10.1007/s10620-010-1263-9 |
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Accordingly, we investigated associations between oral hygiene practices and IBD. Methods We developed and administered a multiple choice questionnaire to evaluate oral hygiene and dental care practices of 137 subjects (83 with IBD and 54 healthy controls). Results Of the 83 IBD cases, 31% had ulcerative colitis and 69% had Crohn's disease. For subjects with IBD, the frequency of brushing at disease onset was significantly higher than in controls (P = 0.005). Also, the frequency of use of dental floss and breath freshener at disease onset was significantly higher in IBD patients (P = 0.005 and <0.001, respectively). Also, patients with IBD more frequently visited their dentist at disease onset (P < 0.001) and continued to visit their dentist more often (P < 0.001). IBD cases had a higher frequency of dental complications such as tooth caries (P = 0.007), oral ulcers (P = 0.04) and dry mouth (P = 0.001). Conclusions These findings suggest that oral hygiene practices may cause alterations in the flora of the oral mucosa, which causes imbalance in the gut microbiome (dysbiosis), and thereby contributes to the pathogenesis of IBD. Conversely, the increased frequency of dental problems in IBD patients might be due, at least in part, to alterations in oral flora or to their disease.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-010-1263-9</identifier><identifier>PMID: 20458622</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adult ; Biochemistry ; Biological and medical sciences ; Care and treatment ; Case-Control Studies ; Colitis, Ulcerative - epidemiology ; Crohn Disease - epidemiology ; Dental care ; Dental hygiene ; Epidemiology. Vaccinations ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Tract - microbiology ; General aspects ; Health aspects ; Health Surveys ; Hepatology ; Humans ; Infectious diseases ; Inflammatory bowel disease ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Mouth ; Mouth Mucosa - microbiology ; Oncology ; Oral Hygiene ; Original Article ; Other diseases. Semiology ; Prevalence ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Toiletries industry ; Transplant Surgery ; Ulcerative colitis ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2011, Vol.56 (1), p.170-175</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-c55577d3a0ded19d80e8c96e8585a0562ae7751fe8722f16c9bebcb1ab6782843</citedby><cites>FETCH-LOGICAL-c524t-c55577d3a0ded19d80e8c96e8585a0562ae7751fe8722f16c9bebcb1ab6782843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23838128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20458622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singhal, Shashideep</creatorcontrib><creatorcontrib>Dian, Delia</creatorcontrib><creatorcontrib>Keshavarzian, Ali</creatorcontrib><creatorcontrib>Fogg, Louis</creatorcontrib><creatorcontrib>Fields, Jeremy Z</creatorcontrib><creatorcontrib>Farhadi, Ashkan</creatorcontrib><title>Role of Oral Hygiene in Inflammatory Bowel Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background The ‘hygiene hypothesis' suggests that a reduction in the microbial exposure due to improved health measures has contributed to an immunological imbalance in the intestine and increased the incidence of autoimmune diseases such as inflammatory bowel diseases (IBD). Accordingly, we investigated associations between oral hygiene practices and IBD. Methods We developed and administered a multiple choice questionnaire to evaluate oral hygiene and dental care practices of 137 subjects (83 with IBD and 54 healthy controls). Results Of the 83 IBD cases, 31% had ulcerative colitis and 69% had Crohn's disease. For subjects with IBD, the frequency of brushing at disease onset was significantly higher than in controls (P = 0.005). Also, the frequency of use of dental floss and breath freshener at disease onset was significantly higher in IBD patients (P = 0.005 and <0.001, respectively). Also, patients with IBD more frequently visited their dentist at disease onset (P < 0.001) and continued to visit their dentist more often (P < 0.001). IBD cases had a higher frequency of dental complications such as tooth caries (P = 0.007), oral ulcers (P = 0.04) and dry mouth (P = 0.001). Conclusions These findings suggest that oral hygiene practices may cause alterations in the flora of the oral mucosa, which causes imbalance in the gut microbiome (dysbiosis), and thereby contributes to the pathogenesis of IBD. Conversely, the increased frequency of dental problems in IBD patients might be due, at least in part, to alterations in oral flora or to their disease.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Colitis, Ulcerative - epidemiology</subject><subject>Crohn Disease - epidemiology</subject><subject>Dental care</subject><subject>Dental hygiene</subject><subject>Epidemiology. Vaccinations</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Health Surveys</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammatory bowel disease</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mouth</subject><subject>Mouth Mucosa - microbiology</subject><subject>Oncology</subject><subject>Oral Hygiene</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Toiletries industry</subject><subject>Transplant Surgery</subject><subject>Ulcerative colitis</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rFDEUhoModq3-AG90UERvpp6TmXxd1vrRQqGg9jpkMifLlJlJTXaR_fdmmdWiSAkkJHneNznnZew5wgkCqPcZQXKoAaFGLpvaPGArFKqpuZD6IVsBlkOOKI_Yk5xvAMAolI_ZEYdWaMn5ivGvcaQqhuoqubE6360Hmqka5upiDqObJreJaVd9iD9prD4OmVymp-xRcGOmZ4f1mF1__vT97Ly-vPpycXZ6WXvB202ZhVCqbxz01KPpNZD2RpIWWjgQkjtSSmAgrTgPKL3pqPMduk4qzXXbHLO3i-9tij-2lDd2GrKncXQzxW22ulRmDGhdyHf3kmhabIQ0AAV99Q96E7dpLnUUP9CADRcFer1AazeSHeYQN8n5vac9VchNa0rbC3XyH6qMnqbBx5nCUM7_EuAi8CnmnCjY2zRMLu0sgt0HapdALez3JVBriubF4b_bbqL-j-J3ggV4cwBc9m4Myc1-yHdcoxuNfN8jvnC5XM1rSneF3_f6y0UUXLRunYrx9TdemgRoOCoDzS_zWbvJ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Singhal, Shashideep</creator><creator>Dian, Delia</creator><creator>Keshavarzian, Ali</creator><creator>Fogg, Louis</creator><creator>Fields, Jeremy Z</creator><creator>Farhadi, Ashkan</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Role of Oral Hygiene in Inflammatory Bowel Disease</title><author>Singhal, Shashideep ; Dian, Delia ; Keshavarzian, Ali ; Fogg, Louis ; Fields, Jeremy Z ; Farhadi, Ashkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-c55577d3a0ded19d80e8c96e8585a0562ae7751fe8722f16c9bebcb1ab6782843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Colitis, Ulcerative - epidemiology</topic><topic>Crohn Disease - epidemiology</topic><topic>Dental care</topic><topic>Dental hygiene</topic><topic>Epidemiology. Vaccinations</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Health Surveys</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammatory bowel disease</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mouth</topic><topic>Mouth Mucosa - microbiology</topic><topic>Oncology</topic><topic>Oral Hygiene</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Toiletries industry</topic><topic>Transplant Surgery</topic><topic>Ulcerative colitis</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singhal, Shashideep</creatorcontrib><creatorcontrib>Dian, Delia</creatorcontrib><creatorcontrib>Keshavarzian, Ali</creatorcontrib><creatorcontrib>Fogg, Louis</creatorcontrib><creatorcontrib>Fields, Jeremy Z</creatorcontrib><creatorcontrib>Farhadi, Ashkan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singhal, Shashideep</au><au>Dian, Delia</au><au>Keshavarzian, Ali</au><au>Fogg, Louis</au><au>Fields, Jeremy Z</au><au>Farhadi, Ashkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Oral Hygiene in Inflammatory Bowel Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2011</date><risdate>2011</risdate><volume>56</volume><issue>1</issue><spage>170</spage><epage>175</epage><pages>170-175</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background The ‘hygiene hypothesis' suggests that a reduction in the microbial exposure due to improved health measures has contributed to an immunological imbalance in the intestine and increased the incidence of autoimmune diseases such as inflammatory bowel diseases (IBD). Accordingly, we investigated associations between oral hygiene practices and IBD. Methods We developed and administered a multiple choice questionnaire to evaluate oral hygiene and dental care practices of 137 subjects (83 with IBD and 54 healthy controls). Results Of the 83 IBD cases, 31% had ulcerative colitis and 69% had Crohn's disease. For subjects with IBD, the frequency of brushing at disease onset was significantly higher than in controls (P = 0.005). Also, the frequency of use of dental floss and breath freshener at disease onset was significantly higher in IBD patients (P = 0.005 and <0.001, respectively). Also, patients with IBD more frequently visited their dentist at disease onset (P < 0.001) and continued to visit their dentist more often (P < 0.001). IBD cases had a higher frequency of dental complications such as tooth caries (P = 0.007), oral ulcers (P = 0.04) and dry mouth (P = 0.001). Conclusions These findings suggest that oral hygiene practices may cause alterations in the flora of the oral mucosa, which causes imbalance in the gut microbiome (dysbiosis), and thereby contributes to the pathogenesis of IBD. Conversely, the increased frequency of dental problems in IBD patients might be due, at least in part, to alterations in oral flora or to their disease.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>20458622</pmid><doi>10.1007/s10620-010-1263-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biochemistry Biological and medical sciences Care and treatment Case-Control Studies Colitis, Ulcerative - epidemiology Crohn Disease - epidemiology Dental care Dental hygiene Epidemiology. Vaccinations Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Tract - microbiology General aspects Health aspects Health Surveys Hepatology Humans Infectious diseases Inflammatory bowel disease Male Medical sciences Medicine Medicine & Public Health Middle Aged Mouth Mouth Mucosa - microbiology Oncology Oral Hygiene Original Article Other diseases. Semiology Prevalence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Toiletries industry Transplant Surgery Ulcerative colitis Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Role of Oral Hygiene in Inflammatory Bowel Disease |
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