Increased Melanocytic Nevi in Patients with Inherited Ichthyoses: Report of a Previously Undescribed Association

:  Ichthyosis is a heterogeneous cornification disorder. Melanocytic lesions have not been previously described in association with ichthyosis. Their clinical importance lies in the fact that they may simulate melanoma clinically and dermoscopically, as seen in epidermolysis bullosa. The objective o...

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Bibliographic Details
Published in:Pediatric dermatology 2010-09, Vol.27 (5), p.453-458
Main Authors: Fernandes, Juliana Dumêt, Rivitti Machado, Maria Cecilia, Oliveira, Zilda Najjar P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biopsy
Brazil - epidemiology
Child
Dermatology
Dyskeratosis
Female
Humans
Ichthyosis - epidemiology
Ichthyosis - genetics
Ichthyosis - pathology
Incidence
Lentigo - epidemiology
Lentigo - pathology
Male
Medical sciences
Nevus, Pigmented - epidemiology
Nevus, Pigmented - pathology
Tumors of the skin and soft tissue. Premalignant lesions
Young Adult
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Summary::  Ichthyosis is a heterogeneous cornification disorder. Melanocytic lesions have not been previously described in association with ichthyosis. Their clinical importance lies in the fact that they may simulate melanoma clinically and dermoscopically, as seen in epidermolysis bullosa. The objective of this study was to evaluate the clinical, dermoscopic, and histopathologic features of nevi and lentigines in 16 patients with autosomal recessive congenital ichthyosis—lamellar ichthyosis and nonbullous ichthyosiform congenital erythroderma. Patients underwent general clinical examination dermoscopy. The more suspicious lesions were excised and to histopathologic examination. Most patients (n = 13) reported no personal or familial history of melanoma or atypical nevi. All of the patients had at least five atypical melanocytic lesions. Ten of the 16 patients had at least one atypical nevus or lentigo. This study suggests that increased atypical melanocytic nevi may be a feature of long‐standing congenital ichthyoses. Whether this finding is disease‐related or a coincidental observation is difficult to ascertain. As an unequivocal discrimination from malignant melanoma in vivo is not always possible, regular clinical follow‐up of patients with ichthyosis and increased or unusual nevi is recommended.
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2010.01092.x