Effect of Heparin on Pathologically Decreased Serum Esterase in Carcinoma

PLASMA and serum esterolytic activity may be considerably decreased in pathological conditions. The substrates most often used for the determination of esterolytic activity are acetylcholine 1 , tributyrine 2 and procaine 3 . Decreased activity is found most often in cirrhosis of the liver and carci...

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Bibliographic Details
Published in:Nature (London) 1958-03, Vol.181 (4613), p.908-909
Main Authors: SKO EPA, J, NOVÁK, Š, TODOROVI OVÁ, H
Format: Article
Language:English
Subjects:
Carcinoma
Esterases - blood
Heparin - pharmacology
Humanities and Social Sciences
Humans
letter
Lymphatic Diseases
multidisciplinary
Neoplasms - blood
Old Medline
Science
Science (multidisciplinary)
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Summary:PLASMA and serum esterolytic activity may be considerably decreased in pathological conditions. The substrates most often used for the determination of esterolytic activity are acetylcholine 1 , tributyrine 2 and procaine 3 . Decreased activity is found most often in cirrhosis of the liver and carcinoma. In our work ethyl butyrate was used as the substrate and esterase activity was determined by the titrimetric method 4 . The values are given in ml. of 0.05 N sodium hydroxide required to neutralize the acid liberated in 24 hr. In agreement with other workers we found low values, especially in some forms of carcinoma and cirrhosis. These low values are in sharp contrast to the increase in esterase activity after administration of heparin. Five minutes after intravenous injection of heparin in amounts of 100 units per kgm. body-weight, the increase reached as much as 780 per cent (Table 1).
ISSN:0028-0836
1476-4687
DOI:10.1038/181908b0