Immunologic Response in Patients with Epiglottitis Caused by Haemophilus influenzae Type B

The sera of 13 patients (median age, 31 months) with epiglottitis caused by Haemophilus influenzae, type b (HIB), were studied for bactericidal, hemagglutinating, and radioimmune assay antibodies to the infecting agent. All 10 patients over two years of age and two of three less than two years of ag...

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Bibliographic Details
Published in:The Journal of infectious diseases 1973-12, Vol.128 (6), p.777-780
Main Authors: Norden, Carl W., Michaels, Richard
Format: Article
Language:English
Subjects:
Adolescent
Antibodies
Antibodies - analysis
Antibody Formation
Blood
Child
Child health services
Child, Preschool
Children
Diseases
Epiglottis - microbiology
Epiglottitis
Haemophilus Infections - immunology
Haemophilus influenzae - immunology
Haemophilus influenzae type b
Humans
Immunology
Infant
Laryngitis - immunology
Middle Aged
Polysaccharides
Polysaccharides, Bacterial
Prospective Studies
Radioimmunoassay
Retrospective Studies
Siblings
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Summary:The sera of 13 patients (median age, 31 months) with epiglottitis caused by Haemophilus influenzae, type b (HIB), were studied for bactericidal, hemagglutinating, and radioimmune assay antibodies to the infecting agent. All 10 patients over two years of age and two of three less than two years of age had significant increases in antibody titers; one child, aged 17 months, showed no rise in antibody titer by any of the three assays. The magnitude of the antibody response correlated with the increasing age of the patients. Nineteen other patients who had HIB epiglottitis six months to 15 years before the period of study and their siblings were bled for determination of their current levels of antibody. Seventyfour percent of patients and only 38% of siblings had detectable bactericidal antibodies to HIB. Two children, who had epiglottitis two and six years previously, and two siblings were immunized with HIB capsular polysaccharide material. All developed specific antibodies by the seventh day after immunization.
ISSN:0022-1899