Blood Level Profile in Man following Chronic Oral Administration of Flurazepam Hydrochloride

• Published in: Journal of pharmaceutical sciences 1973-12, Vol.62 (12), p.1932-1935
• Main Authors: Kaplan, S.A., de Silva, J.A.F., Jack, M.L., Alexander, K., Strojny, N., Weinfeld, R.E., Puglisi, C.V., Weissman, L.
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adult; Benzodiazepines; Benzodiazepines, flurazepam hydrochloride—biotransformation, blood level profile, metabolites; Benzodiazepinones - blood; Biotransformation; Biotransformation-flurazepam hydrochloride after chronic administration; Biotransformation—flurazepam hydrochloride after chronic administration, blood level profile including metabolites, half-lives; blood level profile; blood level profile including metabolites; Blood level profile-flurazepam hydrochloride and metabolites after 14 days administration; Blood level profile—flurazepam hydrochloride and metabolites after 14 days administration, man; Dealkylation; Flurazepam - administration & dosage; Flurazepam - blood; Flurazepam - metabolism; Flurazepam hydrochloride and metabolites-blood level profile in man following 14 days administration; Flurazepam hydrochloride and metabolites—blood level profile in man following 14 days administration, half-lives; flurazepam hydrochloride-biotransformation; Half-Life; half-lives; Humans; Hydroxylation; Hypnotics and Sedatives - blood; Male; man; metabolites; Time Factors
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600621205

The blood level profile of flurazepam and its major metabolites was determined in man following the oral administration of 30mg. daily for 2 weeks. The levels of the intact drug were below the sensitivity limit of the assay (