THE INHIBITION OF MITOCHONDRIAL RESPIRATION BY INHALATIONAL ANAESTHETIC AGENTS

The effects of halothane, methoxyflurane, trichloroethylene, and chloroform on the oxidation of nicotinamide adenine dinudeotide (NAD)-linked substrates by isolated rat liver mitochondria were investigated. All four agents inhibited NADH oxidation at concentrations that did not affect respiration wi...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1973-10, Vol.45 (10), p.1005-1009
Main Authors: HALL, G.M., KIRTLAND, S.J., BAUM, H.
Format: Article
Language:English
Subjects:
Adenosine Diphosphate
Anesthetics - pharmacology
Animals
Chloroform - pharmacology
Electron Transport - drug effects
Halothane - pharmacology
In Vitro Techniques
Methoxyflurane - pharmacology
Mitochondria, Liver - drug effects
NADH, NADPH Oxidoreductases - metabolism
Oxygen Consumption - drug effects
Rats
Succinates
Trichloroethylene - pharmacology
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Summary:The effects of halothane, methoxyflurane, trichloroethylene, and chloroform on the oxidation of nicotinamide adenine dinudeotide (NAD)-linked substrates by isolated rat liver mitochondria were investigated. All four agents inhibited NADH oxidation at concentrations that did not affect respiration with succinate as the substrate. The mean inhibitory concentrations (±SD) for the abolition of stimulation of state IV respiration by ADP were: halothane 0.84 mM (±0.10 mM), methoxyflurane 1.05 mM (±0.25 mM), trichloroethylene 1.11 mM (±0.26 mM), and chloroform 2.62 mM (±0.45 mM). The clinical relevance of this inhibition of electron transfer is discussed.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/45.10.1005