Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma

Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consid...

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Bibliographic Details
Published in:Respiratory medicine 2011-01, Vol.105 (1), p.24-30
Main Authors: Yoshikawa, Takahiro, Kanazawa, Hiroshi
Format: Article
Language:English
Subjects:
Adolescent
Airway narrowing
Animals
Asthma - genetics
Asthma - immunology
Asthma - physiopathology
Asymptomatic airway hyperresponsiveness (AHR)
Biological and medical sciences
Bronchial asthma
Chronic obstructive pulmonary disease, asthma
Clinical remission
Dyspnea - etiology
Dyspnea - physiopathology
Female
Forced Expiratory Volume - physiology
House dust mites
Humans
Immunoglobulin E - immunology
Male
Medical sciences
Perception of dyspnea
Phenotype
Pneumology
Pulmonary/Respiratory
Pyroglyphidae - immunology
Remission, Spontaneous
Respiratory Hypersensitivity - genetics
Respiratory Hypersensitivity - immunology
Respiratory Hypersensitivity - physiopathology
Respiratory system : syndromes and miscellaneous diseases
Spirometry
Young Adult
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Summary:Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consider themselves to be grown out of the disease ( past -asthmatics). Methods Blood parameters, lung function and methacholine PC20 were measured in 88 never -asthmatics and 24 past -asthmatics. A perception score of dyspnea at 20% fall in FEV1 (PS20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV1 curve during methacholine challenge. Results Thirty-one of 88 never -asthmatics and eighteen of 24 past -asthmatics exhibited AHR (PC20 was
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2010.07.015