The Leiodolide B Puzzle

Out of options? Even though a systematic approach was chosen, which led to a set of four diastereomeric macrolides modeled around the proposed structure of leiodolide B (see picture), the puzzle concerning the stereostructure of this cytotoxic metabolite derived from a deep‐sea sponge still remains...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-01, Vol.50 (1), p.304-309
Main Authors: Larivée, Alexandre, Unger, John B., Thomas, Mikaël, Wirtz, Conny, Dubost, Christophe, Handa, Shinya, Fürstner, Alois
Format: Article
Language:English
Subjects:
Biological Products - analysis
Biological Products - chemistry
Biological Products - metabolism
Cytotoxicity
Homogeneous catalysis
Macrolides - analysis
Macrolides - chemistry
Macrolides - metabolism
Magnetic Resonance Spectroscopy
Marine Biology
marine natural products
Metabolites
Molecular Structure
NMR spectroscopy
Oxazoles - analysis
Oxazoles - chemistry
Oxazoles - metabolism
structure elucidation
total synthesis
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Summary:Out of options? Even though a systematic approach was chosen, which led to a set of four diastereomeric macrolides modeled around the proposed structure of leiodolide B (see picture), the puzzle concerning the stereostructure of this cytotoxic metabolite derived from a deep‐sea sponge still remains unsolved.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201005850