Oral Treatment for Mycobacterium ulcerans Infection: Results From a Pilot Study in Benin

Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. The treatment was well tolera...

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Published in:Clinical infectious diseases 2011-01, Vol.52 (1), p.94-96
Main Authors: Chauty, Annick, Ardant, Marie-Françoise, Marsollier, Laurent, Pluschke, Gerd, Landier, Jordi, Adeye, Ambroise, Goundoté, Aimé, Cottin, Jane, Ladikpo, Titilola, Ruf, Therese, Ji, Baohong
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antibiotics
Bacterial diseases
Bacterial infections
Benin
Biological and medical sciences
BRIEF REPORT
Buruli Ulcer - drug therapy
Chemotherapy
Child
Child, Preschool
Clarithromycin - administration & dosage
Clarithromycin - adverse effects
Drug Therapy, Combination - methods
Effectiveness studies
Female
Healing
Histology
Human bacterial diseases
Humans
Infections
Infectious diseases
Lesions
Male
Medical sciences
Medical treatment failures
Middle Aged
Mycobacterium ulcerans
Mycobacterium ulcerans - isolation & purification
Oral ulcers
Patients
Pilot Projects
Polymerase chain reaction
Rifampin - administration & dosage
Rifampin - adverse effects
Treatment Outcome
Tuberculosis and atypical mycobacterial infections
Ulcers
Young Adult
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creator Chauty, Annick
Ardant, Marie-Françoise
Marsollier, Laurent
Pluschke, Gerd
Landier, Jordi
Adeye, Ambroise
Goundoté, Aimé
Cottin, Jane
Ladikpo, Titilola
Ruf, Therese
Ji, Baohong
description Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. The treatment was well tolerated, and all patients were healed by 12 months after initiation of therapy without relapse.
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We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. 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identifier ISSN: 1058-4838
ispartof Clinical infectious diseases, 2011-01, Vol.52 (1), p.94-96
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source Oxford Journals Online; JSTOR
subjects Administration, Oral
Adolescent
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antibiotics
Bacterial diseases
Bacterial infections
Benin
Biological and medical sciences
BRIEF REPORT
Buruli Ulcer - drug therapy
Chemotherapy
Child
Child, Preschool
Clarithromycin - administration & dosage
Clarithromycin - adverse effects
Drug Therapy, Combination - methods
Effectiveness studies
Female
Healing
Histology
Human bacterial diseases
Humans
Infections
Infectious diseases
Lesions
Male
Medical sciences
Medical treatment failures
Middle Aged
Mycobacterium ulcerans
Mycobacterium ulcerans - isolation & purification
Oral ulcers
Patients
Pilot Projects
Polymerase chain reaction
Rifampin - administration & dosage
Rifampin - adverse effects
Treatment Outcome
Tuberculosis and atypical mycobacterial infections
Ulcers
Young Adult
title Oral Treatment for Mycobacterium ulcerans Infection: Results From a Pilot Study in Benin
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