Early Photoinduced Enzymes of Photoinduced Carotenogenesis in a Mycobacterium Species

Some nonphotosynthetic microorganisms synthesize carotenes in response to light. Previous experiments demonstrated that the enzymes necessary for the synthesis and metabolism of phytoene were photoinduced in a Mycobacterium sp. We now report that prephytoene pyrophosphate synthetase is also totally...

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Bibliographic Details
Published in:The Journal of biological chemistry 1974-01, Vol.249 (2), p.402-406
Main Authors: Johnson, Janice H., Reed, Brent C., Rilling, Hans C.
Format: Article
Language:English
Subjects:
Alkenes
Allyl Compounds - metabolism
Carotenoids - biosynthesis
Carotenoids - metabolism
Chromatography, Thin Layer
Darkness
Enzyme Induction
Isomerases - biosynthesis
Light
Mycobacterium - enzymology
Mycobacterium - growth & development
Mycobacterium - metabolism
Organophosphorus Compounds - metabolism
Phosphoric Acids - metabolism
Photic Stimulation
Stereoisomerism
Terpenes - biosynthesis
Transferases - biosynthesis
Tritium
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Summary:Some nonphotosynthetic microorganisms synthesize carotenes in response to light. Previous experiments demonstrated that the enzymes necessary for the synthesis and metabolism of phytoene were photoinduced in a Mycobacterium sp. We now report that prephytoene pyrophosphate synthetase is also totally photoinduced. Geranylgeranyl pyrophosphate synthetase (prenyltransferase), which is present in dark-grown cells, is increased severalfold by photoinduction. The enzymes necessary for the synthesis of high molecular weight (C35 to C40) polyprenyl pyrophosphates and isopentenyl pyrophosphate isomerase were unaffected by photoinduction. This is the first report of the photoinduction of enzymes acting prior to prephytoene pyrophosphate. These enzymes are not restricted to carotene synthesis.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)43044-5