Epithelial–mesenchymal transition in the skin

Abstract Epithelial–mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin...

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Bibliographic Details
Published in:Journal of dermatological science 2011-01, Vol.61 (1), p.7-13
Main Authors: Nakamura, Motonobu, Tokura, Yoshiki
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - metabolism
Dermatology
Epithelial-Mesenchymal Transition - physiology
Epithelial–mesenchymal transition
Fibrosis
Fibrosis - pathology
Humans
Melanoma - etiology
Melanoma - metabolism
Signal Transduction
Skin - growth & development
Skin - metabolism
Skin - pathology
Skin Neoplasms - etiology
Skin Neoplasms - metabolism
SNAI1
Snail
Snail Family Transcription Factors
Systemic sclerosis
Transcription Factors - chemistry
Transcription Factors - metabolism
Wound healing
Wound Healing - physiology
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Description
Summary:Abstract Epithelial–mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, and malignant cutaneous cancers, including squamous cell carcinoma and melanoma.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2010.11.015