Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum

The spectrum of illness and the immunologic response produced by cholera in volunteers were studied. The strains of Vibrio cholerae used were classical Inaba 569B and classical Ogawa 395. An oral dose of 108 organisms in buffered saline was required to induce the diarrhea of cholera. When given with...

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Bibliographic Details
Published in:The Journal of infectious diseases 1974-01, Vol.129 (1), p.45-52
Main Authors: Cash, Richard A., Music, Stanley I., Libonati, Joseph P., Snyder, Merrill J., Wenzel, Richard P., Hornick, Richard B.
Format: Article
Language:English
Subjects:
Administration, Oral
Antibodies, Bacterial
Antitoxins
Bicarbonates - pharmacology
Cholera
Cholera - immunology
Diarrhea
Diarrhea - etiology
Diseases
Feces - microbiology
Gastric Acidity Determination
Gastric Juice - drug effects
Grade 3
Humans
Hydrogen-Ion Concentration
Infections
Major Articles
Male
Vibrio
Vibrio cholerae
Vibrio cholerae - immunology
Vibrio cholerae - isolation & purification
Vibrio cholerae - pathogenicity
Volunteerism
Vomiting
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Summary:The spectrum of illness and the immunologic response produced by cholera in volunteers were studied. The strains of Vibrio cholerae used were classical Inaba 569B and classical Ogawa 395. An oral dose of 108 organisms in buffered saline was required to induce the diarrhea of cholera. When given with live organisms, NaHCO3 lowered the infecting dose from 108 to 104 organisms. Clinical manifestations of infection varied from culturally positive formed stools to “rice water” diarrhea. Severe diarrhea did not have an explosive onset but rather progressively increased in volume during a 24-hr period. In 45 % of cases the stool was positive for V. cholerae before the onset of diarrhea. Titers of vibriocidal antibody rose after diarrhea, peaked the second week after challenge, and rapidly fell during the next four weeks.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/129.1.45