Kinetics of Muscular Contraction in Heavy Water

VARIOUS lines of evidence, for example, involvement of sulphydryl groups and adenosine triphosphatase, suggest that the rate-limiting process for muscular contraction may be proton transfer. In this event, one would expect the rate of either isometric or isotonic contraction to be slowed up in the p...

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Bibliographic Details
Published in:Nature (London) 1958-09, Vol.182 (4636), p.677-677
Main Author: GOODALL, M. C.
Format: Article
Language:English
Subjects:
Deuterium - pharmacology
Deuterium Oxide
Humanities and Social Sciences
Kinetics
letter
multidisciplinary
Muscle Contraction
Muscles - physiology
Old Medline
Physics
Science
Science (multidisciplinary)
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Summary:VARIOUS lines of evidence, for example, involvement of sulphydryl groups and adenosine triphosphatase, suggest that the rate-limiting process for muscular contraction may be proton transfer. In this event, one would expect the rate of either isometric or isotonic contraction to be slowed up in the presence of heavy water (D 2 O). According to a recent analysis 1 , which of the two most affected will depend on whether activation or production of tension is involved.
ISSN:0028-0836
1476-4687
DOI:10.1038/182677a0