Norepinephrine Uptake into Cerebral Cortical Synaptosomes after One Fight or Electroconvulsive Shock

Membrane affinity for the neurotransmitter norepinephrine is rapidly but reversibly decreased in nerve terminals of the cerebral cortex by intense nervous stimulation. This should adaptively facilitate alerting during acute emergency and stress. The Michaelis constant (K$_{m}$) for the high-affinity...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1974-01, Vol.183 (4121), p.220-221
Main Authors: Welch, Bruce L., Hendley, Edith D., Turek, Ibrahim
Format: Article
Language:English
Subjects:
Aggression
Animals
Cerebral cortex
Cerebral Cortex - cytology
Cerebral Cortex - metabolism
Electroconvulsive therapy
Electrodes
Electroshock
Humans
Kinetics
Male
Mice
Nerves
Norepinephrine
Norepinephrine - metabolism
Research facilities
Reuptake
Stress, Physiological - metabolism
Stress, Psychological
Synaptosomes
Synaptosomes - metabolism
Tritium
Velocity
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Summary:Membrane affinity for the neurotransmitter norepinephrine is rapidly but reversibly decreased in nerve terminals of the cerebral cortex by intense nervous stimulation. This should adaptively facilitate alerting during acute emergency and stress. The Michaelis constant (K$_{m}$) for the high-affinity active uptake of norepinephrine into crude synaptosome-rich homogenates of the cerebral cortices of mice was increased 68 percent after 15 minutes of intense fighting and 110 percent 5 minutes after a single electroconvulsive shock. These changes were no longer evident 18 to 20 hours later.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.183.4121.220