The Role of Inflammation in the Pathogenesis of Non-small Cell Lung Cancer

The link between chronic immune activation and tumorigenesis is well established. Compelling evidence has accumulated that histologic assessment of infiltration patterns of different host immune response components in non-small cell lung cancer specimens helps identify different prognostic patient s...

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Bibliographic Details
Published in:Journal of thoracic oncology 2010-12, Vol.5 (12), p.2024-2036
Main Authors: O'Callaghan, Dermot S., O'Donnell, Dearbhaile, O'Connell, Finbarr, O'Byrne, Kenneth J.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Carcinoma, Non-Small-Cell Lung - etiology
CD4-Positive T-Lymphocytes - immunology
Chronic Disease
Humans
Immunity, Cellular
Immunohistochemistry
Inflammation
Inflammation - complications
Lung Neoplasms - etiology
Lymphocyte
Macrophage
Non-small cell lung cancer
Occupational Exposure - adverse effects
Prognosis
Pulmonary Disease, Chronic Obstructive - complications
Tobacco Smoke Pollution - adverse effects
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Summary:The link between chronic immune activation and tumorigenesis is well established. Compelling evidence has accumulated that histologic assessment of infiltration patterns of different host immune response components in non-small cell lung cancer specimens helps identify different prognostic patient subgroups. This review provides an overview of recent insights gained in the understanding of the role played by chronic inflammation in lung carcinogenesis. The usefulness of quantification of different populations of lymphocytes, natural killer cells, macrophages, and mast cells within the tumor microenvironment in non-small cell lung cancer is also discussed. In particular, the importance of assessment of inflammatory cell microlocalization within both the tumor islet and surrounding stromal components is emphasized.
ISSN:1556-0864
1556-1380
DOI:10.1097/JTO.0b013e3181f387e4